I don't use slic3r. Inconsistent results and odd artifacts/movements with it. I use Matter control. One print I make a lot has a large overhang. Slic3r cannot seem to get it. I worried it was my printer. I switched to Mattercontrol and it went away. I get over hangs with perfect results approaching 60 degrees now, I think it could even do better but I haven't tried.

I figured out my splicing problem. It was indeed the extruder distance. What I did to solve it was to insert a G92 EXXXXXXX to what ever the previous layer extruder distance was. Print came out perfect and exactly as I wanted it.