Hi Lambda,
We couldn't agree more. We feel that most of the software out there is catered for a very tech savvy audience. We are making AstroPrint simple enough that anyone can set it up and use it, but the power users can also find all the settings they need.
There will be little to no set up necessary for AstroPrint. We will be offering a pre configured "box" that is simply plug and play. No need to download anything and no need to update.
We definitely have the infill layer height and gcode insertions on our short term development list, the topolabs is something we'll have to look into.