The only issue with larger prints is that more can go wrong the longer the printer is making the model - I've had prints take 12 hours and on the 11th... you guessed it... material warps or unsticks from the platform and an expensive chunk of useless PLA finds its way in the garden. This has been my experience with "consumer" 3D printers... industrial machines are far better though and more accurate so this isn't as much of an issue.

Jon