I'll give Simplify3D a look too.

Here is my first test of Meshmixer. I printed it with Cura. I tried to throw it some curve balls and maybe I was a bit aggressive. I used the Max teapot and added some challenges. The model was 3.5" wide so it was almost 1/2 my build area. It's not huge but not tiny either. The support were left at the default 2mm. I think I need to bump that up to 4mm first thing.

My first print it not spectacular. I have alot of retraction settings to address if I want to clean this up. I see that as the problem. With all the tiny support columns, there is a lot of retraction and destringing going on. Also, everytime the head leaves a column and comes back to the shell, you get a blob. So the outer shell is not perfect. In theory, I like the idea but in practice it may be hard to control and get good surfaces.

MeshMixer_Teapot_Test_01.jpg