If you aren't using dual extruders (which is most of the time for me) then you should minimally remove the nozzle unused nozzle. Preferably remove the left stepper hot end, heatsink/fan and all wiring.

One thing I do on my printers first thing is rewire the print head wires into 2 looms. One for all the left stuff and one for all the right stuff. The cooling fan wires can just be ran up the side of one of the looms.