I wouldn't think so I'm not having any print issues related to the i3 frame.. the only issues I've had are with the heated-bed
and the spring configuration I made for leveling it, autoleveling using a sevo and microswitch needs constand fiddling. I'm doing away with all of that and using a silicone heater attached to an aluminium bed that will be permanently fixed, and will use an inductive probe for bed leveling very similar to the printbot simple.

you've got a nice frame, and I'm sure you will do a good job of making a sturdy y axis frame for it.. it should be good.