yeah narg - how many other programs have you played with ?
I think slic3r is harder to use, cura easier, rep-g just a piece of crap that takes all bloody day to slice even simple models, not tried repetier host.
Makerware is the easiest to use and gives decent results. But has a seriously annoying habit of resetting speed and temps when you click on anything not in the settings tab.

And the beauty of s3d is that once you've got settings that work. They stay saved and always work.

The layout does seperate similiar elements which makes it easier to use.

But it's like everything - you have to learn how to use things to make things.
Programs like makerware that only offer a half dozen options (without the profile editor) are easier to use - but less effective.

I always more detail than less. Which equates to more control.
You can use s3d in idiot mode - where you just pick between different preset settings.
I have ever tried that - as I pretty much change certain things for every print. And they use way more infill than I tend to on most models.

There are many options I've never messed with in s3d - because you don't need to.