Hi

With the proper config, you can get 1.29 to print in the center of the printer. Printing at 0,0 often is a result of having "center at 0,0" checked.

You can get most of the major issues taken care of in Slic3r 1.29 or in the newer versions (if you are even more brave). The minor issues are still going to drive you crazy. One alternative is to grab the Slic3r version off of the Prusa web site and start with it. They have spent some major time taking care of a bunch of the bugs (some of which have been open for years). At this point, their fixes have not been merged back into the "mainline" Slic3r code.

Bob