After struggling with Slic3r, I've moved to Cura. I enjoyed Slic3r's exquisite control over parameters, but other issues led me away from it.

In addition to sharing them, I was hoping for feedback on my medium quality Cura settings. These are for a 10" i3v w/ 1.75mm x .4mm hexagon head and ABS. Use at your own risk. Sufficiently indemnified, here goes:
The retract parameters are based on comments somewhere about here. Temperature is from experiment with MakerFarm vendor glow in the dark green ABS. To help deal with curling of the finished piece, I've been using a brim. The travel speed is probably too low at 100 mm/s. Bottom layer is slow (20mm/s) and fat. Infill is roughed out at 100 mm/s and most printing occurs at 70 mm/s (mostly based on ideas from printbus).

This is a starting point. For each object I print in Cura, I go through a mental checklist and tweak parameters such as infill, wall thickness, brim, support and speed.

[profile]
layer_height = 0.2
wall_thickness = 0.8
retraction_enable = True
solid_layer_thickness = .8
fill_density = 25
nozzle_size = .4
print_speed = 70
print_temperature = 240
print_temperature2 = 0
print_temperature3 = 0
print_temperature4 = 0
print_bed_temperature = 110
support = None
platform_adhesion = Brim
support_dual_extrusion = Both
wipe_tower = False
wipe_tower_volume = 15
ooze_shield = False
filament_diameter = 1.75
filament_diameter2 = 0
filament_diameter3 = 0
filament_diameter4 = 0
filament_flow = 100.0
retraction_speed = 10
retraction_amount = 1
retraction_dual_amount = 16.5
retraction_min_travel = 1.5
retraction_combing = True
retraction_minimal_extrusion = 0.02
retraction_hop = 0.0
bottom_thickness = 0.3
layer0_width_factor = 100
object_sink = 0.0
overlap_dual = 0.15
travel_speed = 100
bottom_layer_speed = 20
infill_speed = 100
inset0_speed = 0
insetx_speed = 100
cool_min_layer_time = 5
fan_enabled = True
skirt_line_count = 1
skirt_gap = 3.0
skirt_minimal_length = 150.0
fan_full_height = 0.5
fan_speed = 100
fan_speed_max = 100
cool_min_feedrate = 10
cool_head_lift = False
solid_top = True
solid_bottom = True
fill_overlap = 15
support_type = Grid
support_angle = 60
support_fill_rate = 15
support_xy_distance = 0.7
support_z_distance = 0.15
spiralize = False
simple_mode = False
brim_line_count = 20
raft_margin = 5.0
raft_line_spacing = 3.0
raft_base_thickness = 0.3
raft_base_linewidth = 1.0
raft_interface_thickness = 0.27
raft_interface_linewidth = 0.4
raft_airgap = 0.22
raft_surface_layers = 2
fix_horrible_union_all_type_a = True
fix_horrible_union_all_type_b = False
fix_horrible_use_open_bits = False
fix_horrible_extensive_stitching = False
plugin_config =
object_center_x = -1
object_center_y = -1


[alterations]
start.gcode = ;Sliced at: {day} {date} {time}
;Basic settings: Layer height: {layer_height} Walls: {wall_thickness} Fill: {fill_density}
;Print time: {print_time}
;Filament used: {filament_amount}m {filament_weight}g
;Filament cost: {filament_cost}
;M190 S{print_bed_temperature} ;Uncomment to add your own bed temperature line
;M109 S{print_temperature} ;Uncomment to add your own temperature line
G21 ;metric values
G90 ;absolute positioning
M82 ;set extruder to absolute mode
M107 ;start with the fan off
G28 X0 Y0 ;move X/Y to min endstops
G28 Z0 ;move Z to min endstops
G1 Z15.0 F{travel_speed} ;move the platform down 15mm
G92 E0 ;zero the extruded length
G1 F200 E3 ;extrude 3mm of feed stock
G92 E0 ;zero the extruded length again
G1 F{travel_speed}
;Put printing message on LCD screen
M117 Printing...
end.gcode = ;End GCode
M104 S0 ;extruder heater off
M140 S0 ;heated bed heater off (if you have it)
G91 ;relative positioning
G1 E-1 F300 ;retract the filament a bit before lifting the nozzle, to release some of the pressure
G1 Z+0.5 E-5 X-20 Y-20 F{travel_speed} ;move Z up a bit and retract filament even more
G28 X0 Y0 ;move X/Y to min endstops, so the head is out of the way
M84 ;steppers off
G90 ;absolute positioning
;{profile_string}
start2.gcode = ;Sliced at: {day} {date} {time}
;Basic settings: Layer height: {layer_height} Walls: {wall_thickness} Fill: {fill_density}
;Print time: {print_time}
;Filament used: {filament_amount}m {filament_weight}g
;Filament cost: {filament_cost}
;M190 S{print_bed_temperature} ;Uncomment to add your own bed temperature line
;M104 S{print_temperature} ;Uncomment to add your own temperature line
;M109 T1 S{print_temperature2} ;Uncomment to add your own temperature line
;M109 T0 S{print_temperature} ;Uncomment to add your own temperature line
G21 ;metric values
G90 ;absolute positioning
M107 ;start with the fan off
G28 X0 Y0 ;move X/Y to min endstops
G28 Z0 ;move Z to min endstops
G1 Z15.0 F{travel_speed} ;move the platform down 15mm
T1 ;Switch to the 2nd extruder
G92 E0 ;zero the extruded length
G1 F200 E10 ;extrude 10mm of feed stock
G92 E0 ;zero the extruded length again
G1 F200 E-{retraction_dual_amount}
T0 ;Switch to the first extruder
G92 E0 ;zero the extruded length
G1 F200 E10 ;extrude 10mm of feed stock
G92 E0 ;zero the extruded length again
G1 F{travel_speed}
;Put printing message on LCD screen
M117 Printing...
end2.gcode = ;End GCode
M104 T0 S0 ;extruder heater off
M104 T1 S0 ;extruder heater off
M140 S0 ;heated bed heater off (if you have it)
G91 ;relative positioning
G1 E-1 F300 ;retract the filament a bit before lifting the nozzle, to release some of the pressure
G1 Z+0.5 E-5 X-20 Y-20 F{travel_speed} ;move Z up a bit and retract filament even more
G28 X0 Y0 ;move X/Y to min endstops, so the head is out of the way
M84 ;steppers off
G90 ;absolute positioning
;{profile_string}
start3.gcode = ;Sliced at: {day} {date} {time}
;Basic settings: Layer height: {layer_height} Walls: {wall_thickness} Fill: {fill_density}
;Print time: {print_time}
;Filament used: {filament_amount}m {filament_weight}g
;Filament cost: {filament_cost}
;M190 S{print_bed_temperature} ;Uncomment to add your own bed temperature line
;M104 S{print_temperature} ;Uncomment to add your own temperature line
;M109 T1 S{print_temperature2} ;Uncomment to add your own temperature line
;M109 T0 S{print_temperature} ;Uncomment to add your own temperature line
G21 ;metric values
G90 ;absolute positioning
M107 ;start with the fan off
G28 X0 Y0 ;move X/Y to min endstops
G28 Z0 ;move Z to min endstops
G1 Z15.0 F{travel_speed} ;move the platform down 15mm
T2 ;Switch to the 2nd extruder
G92 E0 ;zero the extruded length
G1 F200 E10 ;extrude 10mm of feed stock
G92 E0 ;zero the extruded length again
G1 F200 E-{retraction_dual_amount}
T1 ;Switch to the 2nd extruder
G92 E0 ;zero the extruded length
G1 F200 E10 ;extrude 10mm of feed stock
G92 E0 ;zero the extruded length again
G1 F200 E-{retraction_dual_amount}
T0 ;Switch to the first extruder
G92 E0 ;zero the extruded length
G1 F200 E10 ;extrude 10mm of feed stock
G92 E0 ;zero the extruded length again
G1 F{travel_speed}
;Put printing message on LCD screen
M117 Printing...
end3.gcode = ;End GCode
M104 T0 S0 ;extruder heater off
M104 T1 S0 ;extruder heater off
M104 T2 S0 ;extruder heater off
M140 S0 ;heated bed heater off (if you have it)
G91 ;relative positioning
G1 E-1 F300 ;retract the filament a bit before lifting the nozzle, to release some of the pressure
G1 Z+0.5 E-5 X-20 Y-20 F{travel_speed} ;move Z up a bit and retract filament even more
G28 X0 Y0 ;move X/Y to min endstops, so the head is out of the way
M84 ;steppers off
G90 ;absolute positioning
;{profile_string}
start4.gcode = ;Sliced at: {day} {date} {time}
;Basic settings: Layer height: {layer_height} Walls: {wall_thickness} Fill: {fill_density}
;Print time: {print_time}
;Filament used: {filament_amount}m {filament_weight}g
;Filament cost: {filament_cost}
;M190 S{print_bed_temperature} ;Uncomment to add your own bed temperature line
;M104 S{print_temperature} ;Uncomment to add your own temperature line
;M109 T2 S{print_temperature2} ;Uncomment to add your own temperature line
;M109 T1 S{print_temperature2} ;Uncomment to add your own temperature line
;M109 T0 S{print_temperature} ;Uncomment to add your own temperature line
G21 ;metric values
G90 ;absolute positioning
M107 ;start with the fan off
G28 X0 Y0 ;move X/Y to min endstops
G28 Z0 ;move Z to min endstops
G1 Z15.0 F{travel_speed} ;move the platform down 15mm
T3 ;Switch to the 4th extruder
G92 E0 ;zero the extruded length
G1 F200 E10 ;extrude 10mm of feed stock
G92 E0 ;zero the extruded length again
G1 F200 E-{retraction_dual_amount}
T2 ;Switch to the 3th extruder
G92 E0 ;zero the extruded length
G1 F200 E10 ;extrude 10mm of feed stock
G92 E0 ;zero the extruded length again
G1 F200 E-{retraction_dual_amount}
T1 ;Switch to the 2nd extruder
G92 E0 ;zero the extruded length
G1 F200 E10 ;extrude 10mm of feed stock
G92 E0 ;zero the extruded length again
G1 F200 E-{retraction_dual_amount}
T0 ;Switch to the first extruder
G92 E0 ;zero the extruded length
G1 F200 E10 ;extrude 10mm of feed stock
G92 E0 ;zero the extruded length again
G1 F{travel_speed}
;Put printing message on LCD screen
M117 Printing...
end4.gcode = ;End GCode
M104 T0 S0 ;extruder heater off
M104 T1 S0 ;extruder heater off
M104 T2 S0 ;extruder heater off
M104 T3 S0 ;extruder heater off
M140 S0 ;heated bed heater off (if you have it)
G91 ;relative positioning
G1 E-1 F300 ;retract the filament a bit before lifting the nozzle, to release some of the pressure
G1 Z+0.5 E-5 X-20 Y-20 F{travel_speed} ;move Z up a bit and retract filament even more
G28 X0 Y0 ;move X/Y to min endstops, so the head is out of the way
M84 ;steppers off
G90 ;absolute positioning
;{profile_string}
support_start.gcode =
support_end.gcode =
cool_start.gcode =
cool_end.gcode =
replace.csv =
preswitchextruder.gcode = ;Switch between the current extruder and the next extruder, when printing with multiple extruders.
;This code is added before the T(n)
postswitchextruder.gcode = ;Switch between the current extruder and the next extruder, when printing with multiple extruders.
;This code is added after the T(n)