With nylon, you'll certainly want an enclosed printer, one with an all-metal hot end, as the temperatures can reach the point at which a PTFE liner will degrade or otherwise become damaged. I have a Qidi Tech X-Max which is fully enclosed. Additionally, there is a mount for placing the spool inside the enclosure. The videos and supporting documentation I've seen for printing with nylon indicate that it's critical to keep the nylon filament dry. I've read that even a two hour print with the spool external to the enclosure can cause moisture problems.

Some people will build what is called a dry box, but for nylon, you'd want a hot box!