I started using Cura though wanting better quality I started using PrusaSlicer 2.3.0.

This sweet slicer that has Slic3r roots will stand above most Free Slicers and will even put some expensive Slicers to shame.

P.S. There is an Ender 5 Profiles an many filament profiles ready to download from within the PrusaSlicer 2.3.0..