hmm, odd, it's only in the one direction.
have you tried either using a different slicer, or changing the infill direction settings ?

Plus if it's a creality machine - which one ? Could be an x carriage issue if it's an ender (the one z axis motor means the gantry is never exactly level), or a bed issue if one of the others - those central rails with wheel supports do not run level.
Or if just the one side of the machine, the friction between the bowden tube and the filament changes a lot - they're just an awful design.

So with it being new filament, maybe friction on the tube.

I mean with crelity machines you write all the design flaws on a sheet of paper and then throw darts at it to pick the problem :-)