I think so, there is com port config settings and there are 2 exe prusa-slicer and prusa-slicer-console which opens a command window, however I use octoprint so not messing with that at all. The only issue I had is they have removed the check boxes for wait for bed and wait for extruder and you have to add gcode if you want that to happen.. https://github.com/prusa3d/PrusaSlicer/issues/3033. Seems kind of a bad idea as they are trying to make things more plug and play