the empty spots are because at that point the extruder is too close to the build plate to extrude. ie, the build plate is not level.
Now this will cause a build up of molten filament in the extruder the will change how it prints the next bit of the layer.
In other words just having the bit of the bed not level could well effect the entire print.

Apart from your print temp being a little high for pla (try 210), settings are fine.

But your build plate is definitely not level.