I have been using Simplified3D for 2 years (ver 4.01) and have been happy with this version. They really mucked it up when the released a very broken 4.1 and seem to be floundering and unable to update and fix things. So today I pulled down Slic3r 1.3 and gave that a try. Being intimately familiar with S3d made setting up a profile for my printer fairly simple. Once done I exported the config bundle and pulled down Prusa's version of the same software. Much much better, the Prusaslicer is no longer perl based and does not crash or hang. Anyone who uses S3D and knows it well should give the Prusaslicer a try. I have one afternoon in it and the calibration square I have been printing is nicer looking and stronger (2 walls) than what S3D produces, I am very interested to print some of the items I sell to see how they fair.
The profile setup seems to be much more functional than S3D as well.