Originally Posted by
printbus
What happens with the extruder gears when the extrusion stops? If the gears stop moving, focus on the motor. If the motor is getting hot it could be overheating and skipping steps. If the heatsink on the extruder's stepper motor driver is getting hot, the driver chip could be overheating; some add a small fan above the RAMPS board to keep the motor drivers cool. If the set screw on the small gear loosens or falls out, the small gear can start to slip - especially as the printer warms up. Do the gears rotate manually ok, without any catching caused by damaged or clogged gear teeth? If none of these possibilities pan out, maybe try swapping a couple of the motor driver boards around as a last resort.