Will the E3DV6 be compatible with my Wades extruder straight out of the box?
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That all depends on your hotend mount.
In part of Makerfarm Prusa 10" i3v Available!, usarmyaircav was recently dealing with that very question. It appears to need a different thickness mounting plate (6mm vs the 4.5mm one you likely have now).
This whole situation SUCKS :(
I'm gonna try to weld my one and if it doesnt turn out good I'll just buy an E3DV6.
Thanks for all your help guys!